This is looking south at approx. 36.0720N, 82.3987W.
The card was printed by Curt Teich in Chicago. It’s one of the “C” series of post cards issued between 1905 and 1926. The Curt Teich records for this period are scanty and this number isn’t listed anywhere that I can find. Nicely printed, though, and hand colored at the factory before the separations were shot for the print run.